Recent Biochemistry News and Research Highlights (May-June 2021)

Biochemistry News

This year is the 50th anniversary of the Protein Data Bank (PDB). PDB data are used worldwide to answer the fundamental questions about the macromolecular mechanism and function of biological sciences. PDB resources provide important structural features to support structure-based drug design. Read More…

Related Article: Best Discoveries in Cross-coupling Reaction & C-H activation (May-June 2021)

Top Biochemistry Discoveries of the Months, May-June

Among thousands of top-class researchers that publish every month, it’s pretty difficult to pick the best ones; however, the following discoveries really make a difference!

Cardiomyocytes, also known as myocardiocytes are the muscle cells that make up the heart muscle/cardiac muscle. The contractile function of the heart involves cardiomyocytes that enable the pumping of blood around the body. The cell-generated force of cardiomyocytes is crucial for understanding their activity, biomechanical properties, and state of health. The cellular forces are referred to as cell traction forces (CTFs). Cells use traction forces to perform various tasks that include maintaining the cell shape, migrating within tissues, and communicating with neighboring cells. Qiang Zheng et al., recently developed a rapid and ultrahigh-resolution methodology to study the cardiomyocyte behavior at the cellular level. They designed and fabricated a uniform and well-aligned InGaN/GaN nanopillar array, named piezo-phototronic light nano-antenna (PLNA) array, which will be used for CTF quantification. Read More

The large majority of cancers involve dysregulation of telomerase and telomere homeostasis. Telomere length and telomerase activity are crucial for cancer initiation and the survival of tumors. Recently, atomic-resolution structures have been reported providing detailed insights into the molecular mechanism of telomerase. It’s a great way to initiate the rational drug design by targeting telomerase in human genetic disorders and cancer. Read More…

RNA origami has great potential for applications in nanomedicine and synthetic biology is allowing RNA to fold into a particular shape with nanoscale precision. In May 2021, Paul W. K. Rothemund, Ebbe S. Andersen, and co-researchers described the RNA Origami Automated Design software (ROAD), which builds RNA origami models from a library of structural modules. Read More…

Cellular delivery and bioavailability of functional proteins constitute a major challenge for the biological sciences. Cell-penetrating peptides (CPPs) are a fascinating class of peptides that facilitate cellular intake and uptake the molecules ranging from nanosize particles to small molecules to large fragments of DNA. Anselm F L Schneider et al., recently showed that thiol- or HaloTag-reactive additives can result in covalently anchored CPPs on the cell surface, which are highly effective at co-delivering protein cargoes. This new cellular uptake protocol greatly simplifies both the accessibility and efficiency of protein and antibody delivery, with minimal chemical or genetic engineering. Read More…

Related Article: New Nanomaterial Inhibits Liver Cancer via Mild Magnetic Hyperthermia Therapy (MHT)

Dr. Samiran Mondal (Assistant Professor)
Assistant Professor | + posts

Dr. Samiran Mondal is an Assistant Professor at the Department of Chemistry, Rammohan College, Kolkata-700009, West Bengal, India. He is also the former HFSP-Postdoctoral Fellow and worked with Nobel Laureate Prof. (Dr.) Tasuku Honjo at Kyoto University, Japan. His research worked initiated with innovative nanochemistry and further he shifted to cancer immunotherapy research for human welfare.

In the photo, Dr. Samiran Mondal (left) and Prof. (Dr.) Tasuku Honjo (right) are sharing screen together; the snap was taken during his postdoctoral study in Japan.

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